APPLY 3-4 DROPS OF THE SERUM TO YOUR CLEAN FACE AND MASSAGE IT WITH FINGERTIPS UNTIL IT GETS COMPLETELY ABSORBED. APPLY EL PRO RETINOL MOISTURIZER ON THE TOP OF THE SERUM TO COUNTER SENSITIVITY CAUSED BY RETINOL. ONLY AT NIGHT PREFERABLY BEFORE TO BEDTIME. INITIALLY USE EVERY ALTERNATIVE DAY FOR 2 WEEKS AND THEN INCREASE THE FREQUENCY TO EVERY NIGHT AS TOLERATED OR USE AS SUGGESTED BY PHYSICIAN.